Cannabinoid Receptors Modulators
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چکیده
AM 251 ALX-270-239-M001 1 mg ALX-270-239-M005 5 mg Structurally related to the cannabinoid receptor (CB) antagonist SR 141716A. Binds with high affinity to cannabinoid receptor CB1 (Ki=7.49nM; 306-fold selective over CB2 receptors). LIT: Binding of the non-classical cannabinoid CP 55, 940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors: S.J. Gatley, et al.; Life Sci. 61, PL 191 (1997) Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists: R. Lan, et al.; J. Med. Chem. 42, 769 (1999)
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